DTSEA: Drug Target Set Enrichment Analysis

It is a novel tool used to identify the candidate drugs against a particular disease based on the drug target set enrichment analysis. It assumes the most effective drugs are those with a closer affinity in the protein-protein interaction network to the specified disease. (See Gómez-Carballa et al. (2022) <doi:10.1016/j.envres.2022.112890> and Feng et al. (2022) <doi:10.7150/ijms.67815> for disease expression profiles; see Wishart et al. (2018) <doi:10.1093/nar/gkx1037> and Gaulton et al. (2017) <doi:10.1093/nar/gkw1074> for drug target information; see Kanehisa et al. (2021) <doi:10.1093/nar/gkaa970> for the details of KEGG database.)

Version: 0.0.3
Depends: R (≥ 4.0.0)
Imports: dplyr, fgsea, igraph, magrittr, tibble, tidyr, BiocParallel, stringr
Suggests: knitr, rmarkdown
Published: 2022-11-06
DOI: NA
Author: Junwei Han [aut, cre, cph], Yinchun Su [aut]
Maintainer: Junwei Han <hanjunwei1981 at 163.com>
License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
NeedsCompilation: no
Materials: README NEWS
CRAN checks: DTSEA results

Documentation:

Reference manual: DTSEA.pdf
Vignettes: DTSEA User Guide

Downloads:

Package source: DTSEA_0.0.3.tar.gz
Windows binaries: r-devel: DTSEA_0.0.3.zip, r-release: DTSEA_0.0.3.zip, r-oldrel: DTSEA_0.0.3.zip
macOS binaries: r-release (arm64): DTSEA_0.0.3.tgz, r-oldrel (arm64): DTSEA_0.0.3.tgz, r-release (x86_64): DTSEA_0.0.3.tgz, r-oldrel (x86_64): DTSEA_0.0.3.tgz
Old sources: DTSEA archive

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